norethindrone, ethinyl estradiol, and ferrous fumarate

ETH-i-nil es-tra-DYE-ol, nor-ETH-in-drone AS-e-tate, ETH-i-nil es-tra-DYE-ol, FER-us FUE-ma-rate

Oral route(Tablet)

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke .

Commonly used brand name(s)

In the U.S.

• Lo Loestrin Fe

Available Dosage Forms:

• Tablet

Uses For norethindrone, ethinyl estradiol, and ferrous fumarate

Norethindrone, ethinyl estradiol, and ferrous fumarate combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and norethindrone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

norethindrone, ethinyl estradiol, and ferrous fumarate also contains ferrous fumarate. Ferrous fumarate is an iron supplement.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.

norethindrone, ethinyl estradiol, and ferrous fumarate does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

norethindrone, ethinyl estradiol, and ferrous fumarate is available only with your doctor's prescription.

Before Using norethindrone, ethinyl estradiol, and ferrous fumarate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For norethindrone, ethinyl estradiol, and ferrous fumarate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to norethindrone, ethinyl estradiol, and ferrous fumarate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of norethindrone, ethinyl estradiol, and ferrous fumarate combination have not been performed in the pediatric population. However, pediatric-specific problems that would limit the usefulness of this medication in teenagers are not expected. norethindrone, ethinyl estradiol, and ferrous fumarate may be used for birth control in teenage females but should not be used before the start of menstruation.

Geriatric

Appropriate studies on the relationship of age to the effects of norethindrone, ethinyl estradiol, and ferrous fumarate combination have not been performed in the geriatric population. norethindrone, ethinyl estradiol, and ferrous fumarate should not be used in elderly women.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

Ethinyl Estradiol

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Ethinyl EstradiolNorethindrone AcetateIron

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking norethindrone, ethinyl estradiol, and ferrous fumarate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using norethindrone, ethinyl estradiol, and ferrous fumarate with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Boceprevir


• Eltrombopag


• Felbamate


• Isotretinoin


• Paclitaxel


• Paclitaxel Protein-Bound


• Theophylline


• Tizanidine


• Tranexamic Acid

Using norethindrone, ethinyl estradiol, and ferrous fumarate with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alprazolam


• Amoxicillin


• Ampicillin


• Amprenavir


• Aprepitant


• Atazanavir


• Bacampicillin


• Betamethasone


• Bexarotene


• Bosentan


• Carbamazepine


• Cefdinir


• Colesevelam


• Cyclosporine


• Darunavir


• Delavirdine


• Demeclocycline


• Doxycycline


• Efavirenz


• Etravirine


• Fosamprenavir


• Fosaprepitant


• Fosphenytoin


• Gatifloxacin


• Ginseng


• Grepafloxacin


• Griseofulvin


• Lamotrigine


• Levodopa


• Levofloxacin


• Levothyroxine


• Licorice


• Lomefloxacin


• Methyldopa


• Minocycline


• Modafinil


• Moxifloxacin


• Mycophenolate Mofetil


• Mycophenolic Acid


• Nelfinavir


• Nevirapine


• Norfloxacin


• Ofloxacin


• Omeprazole


• Oxcarbazepine


• Oxytetracycline


• Penicillamine


• Phenobarbital


• Phenytoin


• Pioglitazone


• Prednisolone


• Primidone


• Rifabutin


• Rifampin


• Rifapentine


• Ritonavir


• Roflumilast


• Rosuvastatin


• Rufinamide


• Selegiline


• St John's Wort


• Telaprevir


• Temafloxacin


• Tetracycline


• Tipranavir


• Topiramate


• Troglitazone


• Troleandomycin


• Trovafloxacin Mesylate


• Valdecoxib


• Voriconazole


• Warfarin


• Zinc

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using norethindrone, ethinyl estradiol, and ferrous fumarate with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use norethindrone, ethinyl estradiol, and ferrous fumarate, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine


• Dairy Food


• Grapefruit Juice


• Phytic Acid Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of norethindrone, ethinyl estradiol, and ferrous fumarate. Make sure you tell your doctor if you have any other medical problems, especially:

• Abnormal or unusual vaginal bleeding or


• Blood clots, or history of or


• Breast cancer, active or history of or


• Diabetes with kidney, eye, nerve, or blood vessel damage or


• Heart attack, history of or


• Heart or blood vessel disease or


• Heart rhythm problems or


• Hypertension (high blood pressure), uncontrolled or


• Liver disease, including tumors or cancer or


• Migraine headache, new or worse or a new kind of headache or


• Problems with circulation or blood clots, now or in the past or


• Problems with heart valves or


• Stroke, history of—Should not be used in patients with these conditions.

• Angioedema (swelling of the face, tongue, or throat), inherited or


• Cervical cancer or intraepithelial neoplasia or


• Chloasma gravidarum (skin disorder during pregnancy), history of or


• Cholestasis (bile problem) during pregnancy, history of or


• Depression, history of or


• Diabetes or


• Dyslipidemia (high cholesterol or fats in the blood), uncontrolled or


• Gallbladder disease or


• Hypertension (high blood pressure), controlled—Use with caution. May make these conditions worse.

Proper Use of norethindrone, ethinyl estradiol, and ferrous fumarate

To make using hormonal contraceptives as safe and reliable as possible, you should understand how and when to use them and what effects may be expected.

norethindrone, ethinyl estradiol, and ferrous fumarate comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

norethindrone, ethinyl estradiol, and ferrous fumarate is available in blister packs. Each blister pack contains 28 tablets with different colors that need to be taken in the same order as directed on the blister pack.

When you begin using norethindrone, ethinyl estradiol, and ferrous fumarate, your body will require at least 7 days to adjust before a pregnancy will be prevented. Use a second form of contraception, such as a condom, spermicide, or diaphragm, for the first 7 days of your first cycle of pills.

Take norethindrone, ethinyl estradiol, and ferrous fumarate at the same time each day. You may take norethindrone, ethinyl estradiol, and ferrous fumarate with or without food.

Do not skip or delay taking your pill by more than 24 hours. If you miss a dose, you could get pregnant. Ask your doctor for ways to help you remember to take your pills or about using another method of birth control.

You may have light bleeding or spotting when you first take the pill.

You may feel sick or nauseous, especially during the first few months that you take norethindrone, ethinyl estradiol, and ferrous fumarate. If your nausea is continuous and does not go away, call your doctor.

If you vomit or have diarrhea within 3 to 4 hours of taking norethindrone, ethinyl estradiol, and ferrous fumarate, follow the instructions in the patient leaflet or call your doctor.

If you are switching from a combination hormonal method (e.g., another pill, patch, vaginal ring) to using Lo Loestrin Fe®, take the medicine on the day you would have taken your next pill. If you do not start your period, see your doctor for a pregnancy test. If you have used a vaginal ring or patch, finish the 21 days of use, and wait 7 days after the ring or patch is removed before you start taking norethindrone, ethinyl estradiol, and ferrous fumarate. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take norethindrone, ethinyl estradiol, and ferrous fumarate.

If you are switching from a progestin-only method (e.g., progestin-only pill, implant, injection, intrauterine system) to using Lo Loestrin Fe®, take the medicine on the day you would have taken your next progestin-only pill, or on the day your implant is removed, or on the day you would have your next injection. If you switch from an IUD, talk to your doctor when to start taking norethindrone, ethinyl estradiol, and ferrous fumarate. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take norethindrone, ethinyl estradiol, and ferrous fumarate.

Dosing

The dose of norethindrone, ethinyl estradiol, and ferrous fumarate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of norethindrone, ethinyl estradiol, and ferrous fumarate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Your doctor may ask you to begin your dose on the first day of your menstrual period (called Day 1 Start) or on the first Sunday after your menstrual period starts (called Sunday Start). When you begin on a certain day it is important that you follow that schedule, even if you miss a dose. Do not change your schedule on your own. If the schedule that you use is not convenient, check with your doctor about changing it. For a Sunday start, you need to use another form of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days.

• For oral dosage form (tablets):
  
  • For contraception (to prevent pregnancy):
    
    • Adults and teenagers—One tablet taken at the same time each day for 28 days.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using norethindrone, ethinyl estradiol, and ferrous fumarate

It is very important that your doctor check your progress at regular visits to make sure norethindrone, ethinyl estradiol, and ferrous fumarate is working properly and does not cause unwanted effects. These visits will usually be every 6 to 12 months, but some doctors require them more often.

Although you are using norethindrone, ethinyl estradiol, and ferrous fumarate to prevent pregnancy, you should know that using norethindrone, ethinyl estradiol, and ferrous fumarate while you are pregnant could harm the unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is sometimes called spotting when slight, or breakthrough bleeding when heavier.

• If this should occur, continue with your regular dosing schedule.


• The bleeding usually stops within 1 week. Check with your doctor if the bleeding continues for more than 1 week.


• If bleeding continues after you have been taking hormonal contraceptives on schedule and for more than 3 months, check with your doctor.

Check with your doctor right away if you miss a menstrual period. Missed periods may occur if you skip one or more blue tablets and have not taken your pills exactly as directed. If you miss two periods in a row, talk to your doctor. You might need a pregnancy test.

If you suspect that you may be pregnant, stop using norethindrone, ethinyl estradiol, and ferrous fumarate immediately and check with your doctor.

Do not use norethindrone, ethinyl estradiol, and ferrous fumarate if you smoke cigarettes or if you are over 35 years old. If you smoke while using birth control pills, you increase your risk of having a heart attack, stroke, or blood clot. Your risk is even higher if you are over age 35, if you have diabetes, high blood pressure, high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.

Stop using norethindrone, ethinyl estradiol, and ferrous fumarate and check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves; difficulty with breathing; a sudden, severe headache; slurred speech; a sudden, unexplained shortness of breath; a sudden loss of coordination; or vision changes while using norethindrone, ethinyl estradiol, and ferrous fumarate.

Check with your doctor immediately if you have trouble wearing contact lenses or if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Stop using norethindrone, ethinyl estradiol, and ferrous fumarate and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor before refilling an old prescription, especially after a pregnancy. You will need another physical examination and your doctor may change your prescription.

Make sure any doctor or dentist who treats you knows that you are using norethindrone, ethinyl estradiol, and ferrous fumarate. You may need to stop using norethindrone, ethinyl estradiol, and ferrous fumarate several days before having surgery or certain medical tests.

norethindrone, ethinyl estradiol, and ferrous fumarate may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

norethindrone, ethinyl estradiol, and ferrous fumarate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Breast tenderness


• heavy non-menstrual vaginal bleeding


• irregular menstrual periods


• longer or heavier menstrual periods


• normal menstrual bleeding occurring earlier, possibly lasting longer than expected

Incidence not known

• Chest pain


• chills


• clay-colored stools


• confusion


• dark urine


• diarrhea


• difficulty with speaking


• dizziness


• double vision


• fast or irregular heartbeat


• fever


• headache


• inability to move the arms, legs, or facial muscles


• inability to speak


• indigestion


• itching


• loss of appetite


• nausea


• pain, redness, or swelling in the arm or leg


• pains in the chest, groin, or legs, especially in the calves of the legs


• rash


• severe headaches of sudden onset


• severe nausea or vomiting


• slurred speech


• stomach pain


• sudden loss of coordination


• sudden onset of shortness of breath for no apparent reason


• sudden onset of slurred speech


• sudden vision changes


• tightness in the chest


• unpleasant breath odor


• unusual tiredness or weakness


• unusual warmth or flushing of the skin


• unusually heavy or unexpected menstrual bleeding


• vaginal bleeding or spotting


• vomiting of blood


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Vomiting

Less common

• Anxiety


• blemishes on the skin


• cramps


• depression


• heavy bleeding


• pain


• pimples


• weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More norethindrone, ethinyl estradiol, and ferrous fumarate resources

• Norethindrone, ethinyl estradiol, and ferrous fumarate Dosage
• Norethindrone, ethinyl estradiol, and ferrous fumarate Use in Pregnancy & Breastfeeding
• Norethindrone, ethinyl estradiol, and ferrous fumarate Drug Interactions
• Norethindrone, ethinyl estradiol, and ferrous fumarate Support Group
• 654 Reviews for Norethindrone, ethinyl estradiol, and ferrous fumarate - Add your own review/rating

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Ingredient matches for Imadrax

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International Drug Name Search

Theraflu Daytime Severe Cold & Cough

Generic Name: acetaminophen, dextromethorphan, and phenylephrine (a SEET a MIN of fen, DEX troe me THOR fan, and FEN il EFF rin)

Brand Names: Comtrex Cold & Cough, Daytime, Flu & Severe Cold & Cough Daytime Powder, Mapap Cold Formula, Theraflu Daytime Severe Cold & Cough, Theraflu Multi-Symptom Severe Cold, Theraflu Nighttime Severe Cold & Cough, Theraflu Warming Relief Daytime Multi-Symptom Cold, Theraflu Warming Severe Cold Daytime, Tylenol Children's Plus Cold & Cough, Tylenol Cold Multi-Symptom Daytime

What is Theraflu Daytime Severe Cold & Cough (acetaminophen, dextromethorphan, and phenylephrine)?

Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of acetaminophen, dextromethorphan, and phenylephrine is used to treat headache, fever, body aches, cough, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, dextromethorphan, and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about this medicine?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What should I discuss with my healthcare provider before taking this medicine?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take acetaminophen, dextromethorphan, and phenylephrine if you have:

• 
  

  liver disease, cirrhosis, or a history of alcoholism;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  diabetes;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  pheochromocytoma (an adrenal gland tumor); or

  
  


• 
  

  cough with mucus, or cough caused by emphysema or chronic bronchitis.

  
  

It is not known whether acetaminophen, dextromethorphan, and phenylephrine will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant. Acetaminophen, dextromethorphan, and phenylephrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Artificially sweetened cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take this medicine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking this medicine?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen.

This medicine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. chest pain, fast, slow, or uneven heart rate; Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  chest pain, fast, slow, or uneven heart rate;

  
  


• 
  

  severe dizziness, feeling like you might pass out;

  
  


• 
  

  mood changes, confusion, hallucinations;

  
  


• 
  

  tremor, seizure (convulsions);

  
  


• 
  

  fever;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dizziness, weakness;

  
  


• 
  

  mild headache;

  
  


• 
  

  mild nausea, diarrhea, upset stomach;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  feeling nervous, restless, irritable, or anxious; or

  
  


• 
  

  sleep problems (insomnia).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect this medicine?

Ask a doctor or pharmacist if it is safe for you to take this medicine if you are also using any of the following drugs:

• 
  

  leflunomide (Arava);

  
  


• 
  

  tapentadol (Nucynta);

  
  


• 
  

  an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;

  
  


• 
  

  an antidepressant;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  blood pressure medication;

  
  


• 
  

  cancer medicine;

  
  


• 
  

  cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;

  
  


• 
  

  gout or arthritis medications (including gold injections);

  
  


• 
  

  HIV/AIDS medication;

  
  


• 
  

  medicines to treat psychiatric disorders;

  
  


• 
  

  migraine headache medicine;

  
  


• 
  

  an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or

  
  


• 
  

  seizure medication.

  
  

This list is not complete and other drugs may interact with acetaminophen, dextromethorphan, and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Theraflu Daytime Severe Cold & Cough resources

• Theraflu Daytime Severe Cold & Cough Use in Pregnancy & Breastfeeding
• Theraflu Daytime Severe Cold & Cough Drug Interactions
• 0 Reviews for Theraflu Daytime Severe Cold & Cough - Add your own review/rating

• Tylenol Cold Multi-Symptom Daytime Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Theraflu Daytime Severe Cold & Cough with other medications

• Cold Symptoms
• Cough
• Cough and Nasal Congestion
• Nasal Congestion
• Pain/Fever
• Sinus Symptoms
• Tonsillitis/Pharyngitis

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen, dextromethorphan, and phenylephrine.

Niacor

Generic Name: niacin (Oral route)

NYE-a-sin

Commonly used brand name(s)

In the U.S.

• Niacinol


• Niacor


• Niaspan


• Nicotinex


• Slo-Niacin

Available Dosage Forms:

• Tablet


• Tablet, Extended Release


• Capsule


• Capsule, Extended Release


• Elixir

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: Vitamin B

Chemical Class: Nicotinic Acid (class)

Uses For Niacor

Niacin is used to help lower high cholesterol and fat levels in the blood. This may help prevent medical problems caused by cholesterol and fat clogging the blood vessels.

Some strengths of niacin are available only with your doctor's prescription.

Importance of Diet

Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.

Also, Niacor is less effective if you are greatly overweight. It may be very important for you to go on a reducing diet. However, check with your doctor before going on any diet.

Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet.

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing the use of niacin for high cholesterol in children with use in other age groups. However, use is not recommended in children under 2 years of age since cholesterol is needed for normal development.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing the use of niacin for high cholesterol in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atorvastatin


• Cerivastatin


• Lovastatin


• Pitavastatin


• Rosuvastatin


• Simvastatin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or


• Diabetes mellitus (sugar diabetes) or


• Glaucoma or


• Gout or


• Liver disease or history of jaundice


• Low blood pressure or


• Stomach ulcer—Niacin may make these conditions worse

• Kidney problems—Niacin (extended release tablets) may make your kidney problems worse.

Proper Use of niacin

This section provides information on the proper use of a number of products that contain niacin. It may not be specific to Niacor. Please read with care.

Use this medicine only as directed by your doctor. Do not use more or less of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects.

Remember that niacin will not cure your condition but it does help control it. Therefore, you must continue to take it as directed if you expect to keep your cholesterol levels down.

Follow carefully the special diet your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly.

If this medicine upsets your stomach, it may be taken with meals or milk. If stomach upset (nausea or diarrhea) continues, check with your doctor.

For patients taking the extended-release capsule form of this medicine:

• Swallow the capsule whole. Do not crush, break, or chew before swallowing. However, if the capsule is too large to swallow, you may mix the contents of the capsule with jam or jelly and swallow without chewing.

For patients taking the extended-release tablet form of this medicine:

• Swallow the tablet whole. If the tablet is scored, it may be broken, but not crushed or chewed, before being swallowed.


• Tablet (Niaspan) should be taken at bedtime after a low-fat snack.


• To decrease flushing of your face (redness), take aspirin or ibuprofen (e.g., Advil, Motrin) 30 minutes before taking tablet (Niaspan).


• Avoid drinking alcohol or hot drinks around the time you take your tablet (Niaspan). This helps decrease flushing of your face (redness).


• Take this medication exactly as your doctor ordered. If you stop taking this medication for any period of time, contact your doctor prior to restarting taking niacin.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (extended-release capsules, extended-release tablets, oral solution, or regular tablets):
  
  • For treatment of high cholesterol:
    
    • Adults and teenagers—500 milligrams to 2 grams one to three times a day: use and dose will be determined by your doctor. Do not exceed the amount the doctor prescribes.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Niacor

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride (fat) levels and if you should continue to take it.

Do not stop taking niacin without first checking with your doctor. When you stop taking this medicine, your blood cholesterol levels may increase again. Your doctor may want you to follow a special diet to help prevent this from happening.

Do not take vitamins or other dietary supplements unless they have been discussed with your doctor. This especially includes vitamins or dietary supplements that contain niacin or similar ingredients.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

This medicine may cause you to feel dizzy or faint, especially when you get up from a lying or sitting position. Getting up slowly may help. This effect should lessen after a week or two as your body gets used to the medicine. However, if the problem continues or gets worse, check with your doctor.

Niacor Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less commonWith prolonged use of extended-release niacin

• Darkening of urine


• light gray-colored stools


• loss of appetite


• severe stomach pain


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Abdominal pain


• feeling of warmth


• flushing or redness of skin, especially on face and neck


• headache


• rash


• runny nose


• sneezing


• stuffy nose

With high doses

• Diarrhea


• dizziness or faintness


• dryness of skin


• fever


• frequent urination


• itching of skin


• joint pain


• muscle aching or cramping


• nausea or vomiting


• side, lower back, or stomach pain


• swelling of feet or lower legs


• unusual thirst


• unusual tiredness or weakness


• unusually fast, slow, or irregular heartbeat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Niacor side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Niacor resources

• Niacor Side Effects (in more detail)
• Niacor Use in Pregnancy & Breastfeeding
• Drug Images
• Niacor Drug Interactions
• Niacor Support Group
• 0 Reviews for Niacor - Add your own review/rating

• Niacor MedFacts Consumer Leaflet (Wolters Kluwer)


• Niacor Prescribing Information (FDA)


• Niacor nicotinic acid Concise Consumer Information (Cerner Multum)


• Niacin Monograph (AHFS DI)


• Slo-Niacin Controlled-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Niacor with other medications

• High Cholesterol
• Hyperlipoproteinemia
• Hyperlipoproteinemia Type IV, Elevated VLDL
• Hyperlipoproteinemia Type V, Elevated Chylomicrons VLDL
• Niacin Deficiency
• Pellagra

Hemofil M

Pronunciation: an-TIE-hee-moe-FILL-ik
Generic Name: Antihemophilic Factor (Human)
Brand Name: Examples include Alphanate and Hemofil M

Hemofil M is used for:

Preventing and controlling bleeding in patients with factor VII deficiency, also known as hemophilia A, including in surgical settings.

Hemofil M is a human clotting factor derived from pooled human plasma. It works by increasing the amount of clotting factor VII in the blood, helping the blood form clots and stop bleeding.

Do NOT use Hemofil M if:

• you are allergic to any ingredient in Hemofil M or to mouse proteins

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hemofil M:

Some medical conditions may interact with Hemofil M. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Hemofil M. However, no specific interactions with Hemofil M are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hemofil M may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hemofil M:

Use Hemofil M as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Do not shake Hemofil M.


• Hemofil M is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Hemofil M at home, carefully follow the injection procedures taught to you by your health care provider.


• If Hemofil M contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• When drawing a dose into a syringe, be sure to follow the procedure demonstrated to you by your doctor to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.


• Carefully check that you have drawn the correct dose before administration.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Hemofil M, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Hemofil M.

Important safety information:

• Hemofil M may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Hemofil M. Using Hemofil M alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Patients receiving clotting factors sometimes develop antibodies or inhibitors to the medicine. This makes Hemofil M less effective. If Hemofil M stops working or does not work as well as it has before, contact your doctor immediately for instructions.


• Contact your doctor if you develop a fever, drowsiness, chills, or a runny nose followed by a rash and joint pain 2 weeks later.


• Contact your doctor if you develop several days to weeks of poor appetite, tiredness, or low-grade fever followed by nausea, vomiting, and pain in the stomach; dark urine; or a yellowed complexion.


• LAB TESTS, including factor VIII levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.


• Hemofil M is not recommended for use in CHILDREN younger than 16 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Hemofil M during pregnancy. If you are or will be breast-feeding while you are using Hemofil M, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Hemofil M:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anemia; chills; difficulty swallowing; dizziness; fever.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Hemofil M side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Hemofil M:

Store Hemofil M in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Hemofil M may be stored at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), for 2 months. Throw away any unused portion. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hemofil M out of the reach of children and away from pets.

General information:

• If you have any questions about Hemofil M, please talk with your doctor, pharmacist, or other health care provider.


• Hemofil M is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Hemofil M. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Hemofil M resources

• Hemofil M Side Effects (in more detail)
• Hemofil M Use in Pregnancy & Breastfeeding
• Hemofil M Support Group
• 0 Reviews for Hemofil M - Add your own review/rating

Compare Hemofil M with other medications

• Hemophilia A

lapatinib

la-PA-ti-nib

Oral route(Tablet)

Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain .

Commonly used brand name(s)

In the U.S.

• Tykerb

Available Dosage Forms:

• Tablet

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Tyrosine Kinase Inhibitor

Uses For lapatinib

Lapatinib belongs to the group of medicines called antineoplastics or cancer medicines. It is used in combination with capecitabine to treat advanced or metastatic HER2-receptor positive breast cancer (breast cancer that has already spread) after other treatments have failed.

Lapatinib is also used together with letrozole to treat postmenopausal women (women who no longer make estrogen) with hormone-receptor positive and HER2-receptor positive metastatic breast cancer.

Lapatinib interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern.

Before you begin treatment with lapatinib, you and your doctor should talk about the good lapatinib will do as well as the risks of using it.

lapatinib is available only with your doctor's prescription.

Before Using lapatinib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lapatinib, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lapatinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of lapatinib in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lapatinib in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking lapatinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using lapatinib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Dronedarone


• Fluconazole


• Mesoridazine


• Pimozide


• Posaconazole


• Saquinavir


• Sparfloxacin


• Thioridazine

Using lapatinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfuzosin


• Amiodarone


• Amitriptyline


• Amoxapine


• Apomorphine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atazanavir


• Azithromycin


• Carbamazepine


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clozapine


• Crizotinib


• Dasatinib


• Desipramine


• Dexamethasone


• Digoxin


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Erythromycin


• Flecainide


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Imipramine


• Indinavir


• Itraconazole


• Ketoconazole


• Levofloxacin


• Lopinavir


• Lumefantrine


• Mefloquine


• Methadone


• Moxifloxacin


• Nefazodone


• Nelfinavir


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pazopanib


• Perflutren Lipid Microsphere


• Phenobarbital


• Phenytoin


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Rifabutin


• Rifampin


• Rifapentine


• Ritonavir


• Salmeterol


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• St John's Wort


• Sunitinib


• Telavancin


• Telithromycin


• Terfenadine


• Tetrabenazine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimipramine


• Vandetanib


• Vardenafil


• Vemurafenib


• Voriconazole


• Ziprasidone

Using lapatinib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Paclitaxel

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using lapatinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use lapatinib, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of lapatinib. Make sure you tell your doctor if you have any other medical problems, especially:

• Diarrhea or


• Liver disease, history of or


• Lung disease (e.g., interstitial lung disease, pneumonitis), history of—Use with caution. May make these conditions worse.

• Heart disease, history of or


• Heart rhythm problems (e.g., congenital long QT syndrome) or


• Hypokalemia (low potassium in the blood) or


• Hypomagnesemia (low magnesium in the blood)—Use with caution. May cause side effects to become worse.

Proper Use of lapatinib

Medicines used to treat cancer are very strong and can have many side effects. Before receiving lapatinib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take lapatinib exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not change your dose without checking first with your doctor.

lapatinib comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

lapatinib should be taken at least one hour before or one hour after a meal. All of the lapatinib tablets are taken together as one dose each day.

Lapatinib is given together with capecitabine or letrozole. It is important that you take each medicine at the right time. Follow your doctor's instructions on when to take these medicines.

lapatinib often causes diarrhea, nausea, and vomiting. However, it is very important that you continue to receive the medicine even if you begin to feel ill. Your doctor may give you medicines to help prevent these side effects.

Do not eat grapefruit or drink grapefruit juice while you are using lapatinib.

Dosing

The dose of lapatinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lapatinib. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For advanced or metastatic breast cancer with capecitabine:
    
    • Adults—1250 milligrams (mg) or 5 tablets together as a single dose once a day for 21 days. Your doctor may tell you to repeat the 21-day cycle.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For metastatic breast cancer with letrozole:
    
    • Adults—1500 milligrams (mg) or 6 tablets together as a single dose once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of lapatinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using lapatinib

It is very important that your doctor check your progress at regular visits to make sure lapatinib is working properly. Blood tests may be needed to check for unwanted effects.

Using lapatinib while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Serious heart problems can occur with lapatinib. Check with your doctor right away if you are having fast, pounding, or irregular heartbeats; shortness of breath; or unusual tiredness or weakness.

Stop using lapatinib and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; a loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor immediately if severe diarrhea occurs while taking lapatinib. You may need certain medicines to help manage or prevent the diarrhea.

Stop using lapatinib and check with your doctor right away if you start having breathing problems, shortness of breath, a cough, chest pain, fever, or chills. These could be symptoms of a serious lung problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's Wort) or vitamin supplements.

lapatinib Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Difficult or labored breathing


• fainting


• fast or irregular heartbeat


• severe diarrhea


• shortness of breath


• tightness in the chest


• unusual tiredness or weakness


• wheezing

Incidence not known

• Chest pain


• chills


• cough


• fever


• general feeling of discomfort or illness


• thickening of bronchial secretions


• troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• back pain


• belching


• cracked lips


• diarrhea


• difficulty with swallowing


• dry skin


• heartburn


• indigestion


• nausea


• pain in the arms or legs


• rash


• redness, swelling, or painful skin


• scaling of the skin on the hands and feet


• sleeplessness


• sores, ulcers, or white spots on the lips, tongue, or the inside of the mouth


• stomach discomfort, upset, or pain


• swelling or inflammation of the mouth


• tingling of the hands and feet


• trouble sleeping


• unable to sleep


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: lapatinib side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More lapatinib resources

• Lapatinib Side Effects (in more detail)
• Lapatinib Dosage
• Lapatinib Use in Pregnancy & Breastfeeding
• Lapatinib Drug Interactions
• Lapatinib Support Group
• 1 Review for Lapatinib - Add your own review/rating

• Lapatinib MedFacts Consumer Leaflet (Wolters Kluwer)


• Lapatinib Professional Patient Advice (Wolters Kluwer)


• Lapatinib Ditosylate Monograph (AHFS DI)


• Tykerb Prescribing Information (FDA)


• Tykerb Consumer Overview

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Cataflam Immediate-Release Tablets

Pronunciation: dye-KLOE-fen-ak
Generic Name: Diclofenac
Brand Name: Cataflam

Cataflam Immediate-Release Tablets are a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you take Cataflam Immediate-Release Tablets for a long time. Do not use Cataflam Immediate-Release Tablets right before or after bypass heart surgery.

Cataflam Immediate-Release Tablets may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Cataflam Immediate-Release Tablets are used for:

Treating rheumatoid arthritis, osteoarthritis, menstrual pain, or mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Cataflam Immediate-Release Tablets are an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Cataflam Immediate-Release Tablets if:

• you are allergic to any ingredient in Cataflam Immediate-Release Tablets


• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or another NSAID (eg, ibuprofen, celecoxib)


• you have recently had or will be having bypass heart surgery


• you have severe kidney problems


• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cataflam Immediate-Release Tablets:

Some medical conditions may interact with Cataflam Immediate-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)


• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation


• if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), blood vessel disease, or if you are at risk of any of these diseases


• if you have poor health, dehydration or low fluid volume, low blood sodium levels, or you drink alcohol or have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Cataflam Immediate-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), direct factor Xa inhibitors (eg, rivaroxaban), heparin, prasugrel, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of bleeding, including stomach bleeding, may be increased


• Azole antifungals (eg, itraconazole, voriconazole), bisphosphonates (eg, risedronate), or probenecid because they may increase the risk of Cataflam Immediate-Release Tablets's side effects


• Rifamycins (eg, rifampin) because they may decrease Cataflam Immediate-Release Tablets's effectiveness


• Cyclosporine, lithium, methotrexate, other NSAIDs (eg, ibuprofen), quinolones (eg, ciprofloxacin), or tenofovir because the risk of their side effects may be increased by Cataflam Immediate-Release Tablets


• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Cataflam Immediate-Release Tablets


• Medicines that may harm the liver (eg, acetaminophen, ketoconazole, isoniazid, certain medicines for HIV infection, certain antibiotics or seizure medicines) because the risk of liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the liver

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cataflam Immediate-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cataflam Immediate-Release Tablets:

Use Cataflam Immediate-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Cataflam Immediate-Release Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Cataflam Immediate-Release Tablets refilled.


• Take Cataflam Immediate-Release Tablets by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.


• Take Cataflam Immediate-Release Tablets with a full glass of water (8 oz/240 mL) as directed by your doctor.


• If you miss a dose of Cataflam Immediate-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cataflam Immediate-Release Tablets.

Important safety information:

• Cataflam Immediate-Release Tablets may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Cataflam Immediate-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Serious stomach ulcers or bleeding can occur with the use of Cataflam Immediate-Release Tablets. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Cataflam Immediate-Release Tablets with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Cataflam Immediate-Release Tablets are an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do not take aspirin while you are using Cataflam Immediate-Release Tablets unless your doctor tells you to.


• Do not switch between different forms of Cataflam Immediate-Release Tablets (eg, enteric-coated tablets, immediate-release tablets) unless your doctor tells you to. They may not provide the same amount of medicine to your body.


• Lab tests, including kidney and liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Cataflam Immediate-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Cataflam Immediate-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.


• Cataflam Immediate-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Cataflam Immediate-Release Tablets may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cataflam Immediate-Release Tablets while you are pregnant. It is not known if Cataflam Immediate-Release Tablets are found in breast milk. Do not breast-feed while taking Cataflam Immediate-Release Tablets.

Possible side effects of Cataflam Immediate-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Cataflam side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea, vomiting, or stomach pain; slow or troubled breathing; tremor; unusual bleeding or bruising; vomit that looks like coffee grounds.

Proper storage of Cataflam Immediate-Release Tablets:

Store Cataflam Immediate-Release Tablets at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cataflam Immediate-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Cataflam Immediate-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Cataflam Immediate-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Cataflam Immediate-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Cataflam resources

• Cataflam Side Effects (in more detail)
• Cataflam Use in Pregnancy & Breastfeeding
• Drug Images
• Cataflam Drug Interactions
• Cataflam Support Group
• 15 Reviews for Cataflam - Add your own review/rating

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