Miacalcin Injection

Generic Name: calcitonin (Injection route)

kal-si-TOE-nin (SA-man)

Commonly used brand name(s)

In the U.S.

• Miacalcin

Available Dosage Forms:

• Solution


• Injectable

Therapeutic Class: Calcium Regulator

Pharmacologic Class: Calcitonin

Uses For Miacalcin

Calcitonin injection is used to treat Paget's disease of the bone. It may also be used to prevent bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood).

This medicine is available only with your doctor's prescription.

Before Using Miacalcin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of calcitonin injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of calcitonin injection in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Lithium

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Hypocalcemia (low calcium in the blood)—Use with caution. May make this condition worse.

Proper Use of Miacalcin

This medicine is given as a shot under your skin or into one of your muscles. Calcitonin injection may be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure you understand exactly how to use the medicine.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections.

Use a new needle and syringe each time you inject your medicine.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Carefully look at each vial (glass container) of medicine before you use it. Do not use the vial if it appears to be damaged or if the medicine has changed color or has specks (particles) in it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  
  • For Paget's disease:
    
    • Adults—At first, 100 International Units (IU) injected into a muscle or under the skin once a day. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For hypercalcemia:
    
    • Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is 4 International Units (IU) per kilogram (kg) of body weight injected into a muscle or under the skin every 12 hours. Your doctor may adjust your dose as needed. However, the dose is usually not more than 8 IU per kg of body weight every 6 hours.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For postmenopausal osteoporosis:
    
    • Adults—100 International Units (IU) injected into a muscle or under the skin every other day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Miacalcin

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

If you are using this medicine for hypercalcemia (too much calcium in the blood), your doctor may want you to follow a low-calcium diet. If you have any questions about this, check with your doctor.

If you are using this medicine for postmenopausal osteoporosis, your doctor may also want you to take calcium and vitamin D every day. If you have any questions about this, check with your doctor.

Miacalcin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Bloating or swelling of the face, arms, hands, lower legs, or feet


• blurred vision


• chills


• cough


• diarrhea


• difficulty with breathing


• difficulty with moving


• difficulty with swallowing


• dizziness


• fever


• feverish sensation


• frequent urination


• general feeling of discomfort or illness


• headache


• hives


• increased volume of pale, dilute urine


• itching


• joint pain


• loss of appetite


• muscle aches and pains


• muscle or bone pain


• muscle pain or stiffness


• nausea


• nervousness


• noisy breathing


• pounding in the ears


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rapid weight gain


• runny nose


• shivering


• shortness of breath


• skin rash


• slow or fast heartbeat


• sore throat


• sweating


• swelling of the feet


• swelling of the tongue or throat


• swelling or puffiness of the face


• tightness in the chest


• tingling of the hands or feet


• trouble sleeping


• unusual tiredness or weakness


• unusual weight gain or loss


• vomiting


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Red streaks on the skin


• swelling, tenderness, or pain at the injection site

Less common

• Feeling of warmth


• redness of the face, neck, arms, and occasionally, upper chest

Incidence not known

• Abdominal or stomach pain


• blurred or loss of vision


• disturbed color perception


• double vision


• halos around lights


• increased urge to urinate during the night


• itching of the ear lobes


• night blindness


• overbright appearance of lights


• pain in the eyes


• poor appetite


• salty taste


• tunnel vision


• waking to urinate at night

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Miacalcin Injection side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More Miacalcin Injection resources

• Miacalcin Injection Side Effects (in more detail)
• Miacalcin Injection Use in Pregnancy & Breastfeeding
• Miacalcin Injection Drug Interactions
• Miacalcin Injection Support Group
• 0 Reviews for Miacalcin Injection - Add your own review/rating

Compare Miacalcin Injection with other medications

• Hypercalcemia
• Osteogenesis Imperfecta
• Osteoporosis
• Paget's Disease

Veletri

Generic Name: epoprostenol (EE poe PROST en ol)

Brand Names: Flolan, Veletri

What is Veletri (epoprostenol)?

Epoprostenol is a prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.

Epoprostenol is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise.

Epoprostenol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Veletri (epoprostenol)?

You should not use this medication if you are allergic to epoprostenol, if you have breathing problems when you first start using epoprostenol, or if you have congestive heart failure caused by a decrease in your heart's ability to pump blood back into the body.

Before using epoprostenol, tell your doctor if you have a bleeding or blood clotting disorder, heart disease, liver or kidney disease, or high blood pressure.

Epoprostenol is injected into a vein using an infusion pump, usually through a permanent central intravenous (IV) catheter placed into a large vein (such as in your chest). You may need to use this medication for many years.

You may be shown how to use an infusion pump at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

You will receive your first dose of this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Your blood pressure and heart rate may also need to be monitored whenever your dose is changed.

Tell your doctor about all other drugs you use, especially medicines to prevent blood clots.

Do not stop using epoprostenol without first talking to your doctor, even if you feel fine or have no symptoms. Even short breaks in the flow of your medication through the IV can cause the treatment to stop working. Missing doses or stopping suddenly may make your condition worse and you may have symptoms such as dizziness, weakness, or trouble breathing. Call your doctor if your symptoms do not improve, or if they get worse while using epoprostenol.

What should I discuss with my healthcare provider before using Veletri (epoprostenol)?

You should not use this medication if you are allergic to epoprostenol, if you have breathing problems when you first start using epoprostenol, or if you have congestive heart failure caused by a decrease in your heart's ability to pump blood back into the body.

To make sure you can safely use epoprostenol, tell your doctor if you have any of these other conditions:

• 
  

  a bleeding or blood clotting disorder;

  
  


• 
  

  heart disease;

  
  


• 
  

  high blood pressure;

  
  


• 
  

  kidney disease; or

  
  


• 
  

  liver disease.

  
  

FDA pregnancy category B. Epoprostenol is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether epoprostenol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Veletri (epoprostenol)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. You may need to use this medication for many years.

Epoprostenol is injected into a vein using a computerized, portable infusion pump to control the rate of medication you receive. Because epoprostenol must be used long-term, it is usually given through a permanent central intravenous (IV) catheter placed into a large vein (such as in your chest).

You may be shown how to use an infusion pump at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

You will receive your first dose of this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Your blood pressure and heart rate may also need to be monitored whenever your dose is changed.

You may be given other medications to prevent blood clots while you are receiving epoprostenol.

Epoprostenol is a powder medicine that must be mixed with a liquid (diluent) before using it. Use only the diluent provided with your medication and do not mix epoprostenol with any other medications or diluents not approved by your doctor.

If you are using the injections at home, be sure you understand how to properly mix and store the medicine. These directions are different for the Flolan and Veletri brands of this medication. Be sure you understand all mixing and storage directions for the specific brand of epoprostenol you are using.

After mixing Flolan with the diluent, store in the refrigerator and use within 48 hours. After mixing Veletri with the diluent, store in the refrigerator ans use within 5 days. The Veletri and diluent mixture may also be stored at room temperature but you must use it within 48 hours after it was mixed. Protect the mixed medicine from light and do not freeze. Throw away any epoprostenol and diluent mixture that has become frozen, has changed colors, or has any particles in it. Call your doctor for a new prescription. The epoprostenol and diluent mixture must be protected from light at all times, whether it is in storage or in use. Do not stop using epoprostenol without first talking to your doctor, even if you feel fine or have no symptoms. Missing doses or stopping suddenly may make your condition worse and you may have symptoms such as dizziness, weakness, or trouble breathing.

Even short breaks in the flow of your medication through the IV can cause the treatment to stop working. To make sure there is no interruption in your treatment, you may need to have a back-up infusion pump in case your first pump fails to work properly. Also keep replacement batteries and extra IV infusion sets on hand at all times. Get your prescription refilled before you run out of medicine completely.

Call your doctor if your symptoms do not improve, or if they get worse while using epoprostenol. Store unopened vials of epoprostenol and its diluent at cool room temperature (below 77 degrees F), away from moisture, heat, and light. Keep in the original carton.

What happens if I miss a dose?

Because this medication is given around the clock, you should not miss a dose if you use the medication properly. Call your doctor right away if your epoprostenol therapy is interrupted for any reason.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using Veletri (epoprostenol)?

Avoid using any infusion pump that has not been approved for use by your doctor.

Veletri (epoprostenol) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fever, flu symptoms, mouth and throat ulcers, rapid heart rate, rapid and shallow breathing, fainting;

  
  


• 
  

  chest pain, trouble breathing;

  
  


• 
  

  fast, slow, or uneven heart rate;

  
  


• 
  

  pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  
  


• 
  

  blood in your urine or stools;

  
  


• 
  

  coughing up blood;

  
  


• 
  

  feeling like you might pass out; or

  
  


• 
  

  numbness or increased sensitivity anywhere in your body.

  
  

Less serious side effects may include:

• 
  

  flushing (warmth, redness, or tingly feeling);

  
  


• 
  

  nausea, vomiting, diarrhea, stomach pain;

  
  


• 
  

  headache or jaw pain;

  
  


• 
  

  joint or muscle pain;

  
  


• 
  

  dizziness, sweating; or

  
  


• 
  

  feeling anxious, nervous, or agitated.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Veletri (epoprostenol)?

Epoprostenol can increase your risk of bleeding. This effect is increased when you also use medicines to prevent blood clots, such as:

• 
  

  heparin or warfarin (Coumadin, Jantoven);

  
  


• 
  

  alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);

  
  


• 
  

  dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep); or

  
  


• 
  

  abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).

  
  

Tell your doctor about all other medications you use, especially:

• 
  

  digoxin (digitalis, Lanoxin);

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  heart or blood pressure medications;

  
  


• 
  

  aspirin or an NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

  
  

This list is not complete and other drugs may interact with epoprostenol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Veletri resources

• Veletri Side Effects (in more detail)
• Veletri Use in Pregnancy & Breastfeeding
• Veletri Drug Interactions
• Veletri Support Group
• 0 Reviews for Veletri - Add your own review/rating

• Veletri MedFacts Consumer Leaflet (Wolters Kluwer)


• Veletri Advanced Consumer (Micromedex) - Includes Dosage Information


• Veletri Prescribing Information (FDA)


• Epoprostenol Prescribing Information (FDA)


• Epoprostenol Sodium Monograph (AHFS DI)


• Flolan Prescribing Information (FDA)

Compare Veletri with other medications

• Pulmonary Arterial Hypertension

Where can I get more information?

• Your doctor or pharmacist can provide more information about epoprostenol.

See also: Veletri side effects (in more detail)

Up and Up Minoxidil

Generic Name: minoxidil

Dosage Form: solution
Target Corp. Minoxidil Topical Solution USP 2% Drug Facts

Active ingredient

Minoxidil 2% w/v

Purpose

Hair regrowth treatment

Uses

to regrow hair on the scalp

Warnings

For external use only

Flammable: Keep away from fire or flame

Do not use if

• your degree of hair loss is different than that shown on the side of this carton, because this product may not work for you


• you have no family history of hair loss


• your hair loss is sudden and/or patchy


• your hair loss is associated with childbirth


• you do not know the reason for your hair loss


• you are under 18 years of age. Do not use on babies and children.


• your scalp is red, inflamed, infected, irritated, or painful


• you use other medicines on the scalp

Ask a doctor before use if you have

heart disease

When using this product

• do not apply on other parts of the body


• avoid contact with the eyes. In case of accidental contact, rinse eyes with large amounts of cool tap water.


• some people have experienced changes in hair color and/or texture


• it takes time to regrow hair. You may need to use this product 2 times a day for at least 4 months before you see results.


• the amount of hair regrowth is different for each person. This product will not work for everyone.

Stop use and ask a doctor if

• chest pain, rapid heartbeat, faintness, or dizziness occurs


• sudden, unexplained weight gain occurs


• your hands or feet swell


• scalp irritation or redness occurs


• unwanted facial hair growth occurs


• you do not see hair regrowth in 4 months

May be harmful if used when pregnant or breast-feeding.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

• apply one mL with dropper 2 times a day directly onto the scalp in the hair loss area


• using more or more often will not improve results


• continued use is necessary to increase and keep your hair regrowth, or hair loss will begin again

Other information

• see hair loss pictures on side of this carton


• before use, read all information on carton and enclosed leaflet


• keep the carton. It contains important information.


• in clinical studies of mostly white women aged 18-45 years with mild to moderate degrees of hair loss, the following response to minoxidil topical solution 2% was reported: 19% of women reported moderate hair regrowth after using minoxidil topical solution 2% for 8 months (19% had moderate regrowth; 40% had minimal regrowth). This compares with 7% of women reporting moderate hair regrowth after using the placebo, the liquid without minoxidil in it, for 8 months (7% had moderate regrowth; 33% had minimal regrowth).


• store at 20° to 25°C (68° to 77°F). Keep tightly closed.

Inactive ingredients

alcohol, propylene glycol, purified water

Questions?

Call 1-800-910-6874

Principal Display Panel

Minoxidil Topical Solution USP 2%

Hair Regrowth Treatment

Compare to active ingredient in Women’s Rogaine®

For Women

Clinically Proven to Help Regrow Hair

Revitalizes Hair Follicles

# Month Supply

Minoxidil Topical Solution USP 2% Carton

Up and Up Minoxidil  minoxidil  solution

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 11673-856 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength MINOXIDIL (MINOXIDIL) MINOXIDIL 2 g  in 100 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 11673-856-30 3 BOTTLE In 1 CARTON contains a BOTTLE 1 60 mL In 1 BOTTLE This package is contained within the CARTON (11673-856-30)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA075357	05/27/2009

Labeler - Target Corporation (006961700)

Revised: 07/2009Target Corporation

More Up and Up Minoxidil resources

• Up and Up Minoxidil Use in Pregnancy & Breastfeeding
• Up and Up Minoxidil Drug Interactions
• Up and Up Minoxidil Support Group
• 7 Reviews for Up and Up Minoxidil - Add your own review/rating

Compare Up and Up Minoxidil with other medications

• Alopecia

Capsicum Oleoresin

Generic Name: capsaicin topical (kap SAY sin TOP i kal)

Brand Names: Axsain, Capsicum Oleoresin, Capsin, Capzasin Back and Body, Capzasin Quick Relief, Capzasin-HP, Capzasin-P, Castiva Warming, Dolorac, Icy Hot PM, Icy Hot with Capsaicin, Menthac Arthritis Cream with Capsaicin, Qutenza, Salonpas Gel-Patch, Salonpas Pain Patch with Capsaicin, Sloan's Liniment, Trixaicin, Trixaicin HP, Zostrix, Zostrix Diabetic Foot Pain, Zostrix Foot Pain, Zostrix Neuropathy, Zostrix Sports, Zostrix-HP

What is Capsicum Oleoresin (capsaicin topical)?

Capsaicin is the active ingredient in chili peppers that makes them hot. Capsaicin is used in medicated creams and lotions to relieve muscle or joint pain.

Capsaicin used on the body causes a sensation of heat that activates certain nerve cells. With regular use of capsaicin, this heating effect reduces the amount of substance P, a chemical that acts as a pain messenger in the body.

Capsaicin topical is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Capsaicin topical is also used to treat nerve pain (neuralgia) in people who have had herpes zoster, or "shingles."

Capsaicin topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Capsicum Oleoresin (capsaicin topical)?

Do not use this medication if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical.

Ask a doctor or pharmacist about using capsaicin topical if you have any allergies or serious medical conditions. Do not use this medication on anyone younger than 18 years old without the advice of a doctor.

Capsaicin can cause a burning sensation, which is usually mild and should lessen over time with continued use. If the burning sensation causes significant discomfort, wash the treated skin area with soap and cool water. Stop using the medication and call your doctor if you have severe burning or redness where the medicine was applied.

Avoid getting capsaicin topical in your mouth or eyes or near your nose.

Do not apply to open wounds or irritated skin, and avoid getting the medicine on contact lenses, dentures, and other items that come into contact with sensitive areas of your body.

Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. Accidental swallowing of capsaicin can cause problems with swallowing or breathing.

It may take up to 2 weeks of using this medicine regularly before your symptoms improve. For best results, keep using the medication as directed.

Call your doctor if your pain does not improve after using this medication for 7 days, or if your symptoms get worse or get better and then come back in a few days.

What should I discuss with my healthcare provider before using Capsicum Oleoresin (capsaicin topical)?

Do not use this medication if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical.

Ask a doctor or pharmacist about using capsaicin topical if you have any allergies (especially to plants), or if you have a serious medical condition.

It is not known whether capsaicin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether capsaicin topical passes into breast milk or if it could harm a nursing baby. Do not apply capsaicin topical to your breast area if you are breast-feeding a baby. Do not use this medication on anyone younger than 18 years old without the advice of a doctor.

How should I use Capsicum Oleoresin (capsaicin topical)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Capsaicin can cause a burning sensation wherever it is applied. This sensation is usually mild and should gradually lessen over time with continued regular use of the medicine.

Do not apply capsaicin topical to open wounds, or to skin that is sunburned, windburned, dry, chapped, or otherwise irritated. Do not get this medication in your mouth or eyes, or near your nose where you might inhale it. If it does get into any of these areas, rinse thoroughly with water.

Also avoid getting this medication on contact lenses, dentures, and other items that come into contact with sensitive areas of your body.

To keep the medication from getting on your fingers when you apply it, you may use a rubber glove, finger cot, cotton ball, or clean tissue to apply the medicine.

Make sure your skin is clean and dry before you apply capsaicin topical.

When using capsaicin topical cream or lotion, apply a thin layer to the affected area and rub in gently until completely absorbed.

To use capsaicin topical liquid or stick, uncap the applicator and press it firmly on your skin to apply the medication. Massage gently onto the affected are until completely absorbed.

Capsaicin topical may be used up to 4 times daily or as directed on the medicine label.

To apply a capsaicin topical patch, remove the liner and apply the patch to your skin over the area of pain. Press the edges firmly into place. Remove the patch and apply a new patch 1 or 2 times daily if needed.

Wash your hands with soap and water immediately after applying capsaicin topical or handling the topical patch. If you have applied the medicine to your hands or fingers to treat pain in those areas, wait at least 30 minutes before washing your hands. Do not cover treated skin with a bandage or heating pad, which can increase the burning sensation. You may cover the skin with clothing.

Avoid taking a bath or shower within 1 hour before or after you apply capsaicin topical to your skin. Also avoid swimming or vigorous exercise. Warm water or perspiration can increase the burning sensation caused by capsaicin.

If the burning sensation caused by capsaicin is painful or causes significant discomfort, wash the treated skin area with soap and cool water.

It may take up to 2 weeks of using this medicine regularly before your symptoms improve. For best results, keep using the medication as directed. Pain relief should occur gradually as the substance P in your body is decreased in the nerve cells.

Call your doctor if your pain does not improve after using this medication for 7 days, or if your symptoms get worse or get better and then come back in a few days. Store capsaicin topical at room temperature away from moisture and heat, in a place where children and pets cannot get to it.

Capsaicin topical liquid is flammable. Do not use or store near fire or open flame.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not apply capsaicin more than 4 times in one day, or use extra medicine to make up a missed dose .

A missed dose of capsaicin topical will not cause harm but may make the medication less effective reducing substance P and relieving your pain.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if anyone has accidentally swallowed it.

Accidental swallowing of capsaicin can cause severe burning in or around the mouth, watery eyes, runny nose, and trouble swallowing or breathing.

Applying too much capsaicin topical to the skin can cause severe burning or redness.

What should I avoid while using Capsicum Oleoresin (capsaicin topical)?

Avoid inhaling the odor or dried residue of capsaicin topical. Inhaling capsaicin can cause coughing, sneezing, or watery eyes, and can irritate your throat or lungs.

Avoid touching your eyes, mouth, nose, genitals, or rectum until the medication has been washed off your hands. Also avoid handling food while the medication is still on your hands.

Avoid exposing treated skin to sunlight, sunlamps, tanning beds, or a hot tub. Capsaicin can cause a burning sensation that may be made worse by heat.

Do not use other medicated skin products, including muscle pain creams or lotions, on areas where you have applied capsaicin, unless your doctor has told you to.

Capsicum Oleoresin (capsaicin topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using capsaicin topical and call your doctor at once if you have a serious side effect such as:

• 
  

  severe burning or irritation where the medicine was applied;

  
  


• 
  

  skin redness where the medicine was applied; or

  
  


• 
  

  trouble breathing or swallowing (after accidental inhalation of capsaicin odor or dried residue).

  
  

Less serious side effects may include a mild burning sensation that can last for several hours or days, especially after your first use of capsaicin topical.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Capsicum Oleoresin (capsaicin topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied capsaicin. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Capsicum Oleoresin resources

• Capsicum Oleoresin Side Effects (in more detail)
• Capsicum Oleoresin Use in Pregnancy & Breastfeeding
• Capsicum Oleoresin Drug Interactions
• Capsicum Oleoresin Support Group
• 0 Reviews for Capsicum Oleoresin - Add your own review/rating

• Axsain Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Axsain Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Capzasin-P Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Qutenza Prescribing Information (FDA)


• Qutenza Consumer Overview


• Qutenza Patch MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Capsicum Oleoresin with other medications

• Diabetic Nerve Damage
• Osteoarthritis
• Pain
• Persisting Pain, Shingles

Where can I get more information?

• Your pharmacist can provide more information about capsaicin topical.

See also: Capsicum Oleoresin side effects (in more detail)

Matulane

Generic Name: procarbazine (Oral route)

proe-KAR-ba-zeen

Oral route(Capsule)

Adequate clinical and laboratory facilities should be available to patients treated with procarbazine for proper monitoring of treatment .

Commonly used brand name(s)

In the U.S.

• Matulane

Available Dosage Forms:

• Capsule

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Alkylating Agent

Uses For Matulane

Procarbazine belongs to the group of medicines known as alkylating agents. It is used to treat some kinds of cancer.

Procarbazine is thought to interfere with the growth of cancer cells which are eventually destroyed. It also blocks the action of a chemical substance in the central nervous system called monoamine oxidase (MAO), but this is probably not related to its effect against cancer. Since the growth of normal body cells may also be affected by procarbazine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with procarbazine, you and your doctor should talk about the good this medicine will do as well as the risks of using it.

Procarbazine is available only with your doctor's prescription.

Before Using Matulane

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information about the use of procarbazine in children, it is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Side effects may be more likely to occur in elderly patients, who are usually more sensitive to the effects of procarbazine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amitriptyline


• Amphetamine


• Apraclonidine


• Atomoxetine


• Benzphetamine


• Brimonidine


• Bupropion


• Carbamazepine


• Citalopram


• Cyclobenzaprine


• Cyproheptadine


• Desvenlafaxine


• Dexfenfluramine


• Dexmethylphenidate


• Dextroamphetamine


• Dextromethorphan


• Diethylpropion


• Duloxetine


• Fenfluramine


• Fluoxetine


• Guanadrel


• Guanethidine


• Isocarboxazid


• Isometheptene


• Levodopa


• Levomethadyl


• Linezolid


• Lisdexamfetamine


• Maprotiline


• Mazindol


• Meperidine


• Methamphetamine


• Methyldopa


• Methylphenidate


• Milnacipran


• Morphine


• Morphine Sulfate Liposome


• Nefopam


• Opipramol


• Paroxetine


• Phendimetrazine


• Phenelzine


• Phenmetrazine


• Phentermine


• Phenylalanine


• Phenylephrine


• Phenylpropanolamine


• Procarbazine


• Pseudoephedrine


• Rasagiline


• Reserpine


• Rizatriptan


• Rotavirus Vaccine, Live


• Selegiline


• Sertraline


• Sibutramine


• Sumatriptan


• Tapentadol


• Tetrabenazine


• Tranylcypromine


• Venlafaxine


• Vilazodone


• Zolmitriptan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetophenazine


• Adenovirus Vaccine Type 4, Live


• Adenovirus Vaccine Type 7, Live


• Albuterol


• Altretamine


• Amoxapine


• Arformoterol


• Avocado


• Bacillus of Calmette and Guerin Vaccine, Live


• Bambuterol


• Bitolterol


• Bitter Orange


• Broxaterol


• Buspirone


• Chlorpromazine


• Clenbuterol


• Clomipramine


• Clovoxamine


• Desipramine


• Difenoxin


• Diphenoxylate


• Dixyrazine


• Dothiepin


• Doxepin


• Droperidol


• Entacapone


• Ephedrine


• Ethchlorvynol


• Ethopropazine


• Femoxetine


• Fenoterol


• Fentanyl


• Fluphenazine


• Fluvoxamine


• Formoterol


• Guarana


• Hexoprenaline


• Hydromorphone


• Imipramine


• Indacaterol


• Influenza Virus Vaccine, Live


• Isoetharine


• Kava


• Levalbuterol


• Licorice


• Lofepramine


• Ma Huang


• Mate


• Measles Virus Vaccine, Live


• Mesoridazine


• Methotrimeprazine


• Mirtazapine


• Mumps Virus Vaccine, Live


• Nefazodone


• Nortriptyline


• Oxycodone


• Perazine


• Periciazine


• Perphenazine


• Pipotiazine


• Pirbuterol


• Procaterol


• Prochlorperazine


• Promazine


• Promethazine


• Propiomazine


• Protriptyline


• Reboxetine


• Rimiterol


• Ritodrine


• Rotavirus Vaccine, Live


• Rubella Virus Vaccine, Live


• Salmeterol


• Smallpox Vaccine


• St John's Wort


• Sumatriptan


• Terbutaline


• Thiethylperazine


• Thioridazine


• Tolcapone


• Trifluoperazine


• Triflupromazine


• Trimipramine


• Tulobuterol


• Typhoid Vaccine


• Tyrosine


• Varicella Virus Vaccine


• Warfarin


• Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose


• Acetohexamide


• Benfluorex


• Chlorpropamide


• Ginseng


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Guar Gum


• Insulin


• Insulin Aspart, Recombinant


• Insulin Glulisine


• Insulin Lispro, Recombinant


• Metformin


• Methotrexate


• Miglitol


• Repaglinide


• Tolazamide


• Tolbutamide


• Troglitazone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Tyramine Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcoholism

• Angina (chest pain) or


• Heart or blood vessel disease or


• Heart attack or stroke (recent)—Lowered blood pressure caused by procarbazine may make problems associated with some of these conditions worse

• Chickenpox (including recent exposure) or


• Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body

• Type 2 diabetes mellitus—Procarbazine may change the amount of diabetes medicine needed

• Epilepsy—Procarbazine may change the seizures

• Headaches (severe or frequent)—You may not realize when a severe headache is caused by a dangerous reaction to procarbazine

• Infection—Procarbazine can reduce immunity to infection

• Kidney disease—Effects may be increased because of slower removal of procarbazine from the body

• Liver disease—Procarbazine can cause severe liver disease to become much worse

• Mental illness (or history of)—Some cases of mental illness may be worsened

• Overactive thyroid—Increased risk of dangerous reaction to procarbazine

• Parkinson's disease—May be worsened

• Pheochromocytoma—Blood pressure may be affected

Proper Use of Matulane

Use this medicine only as directed by your doctor. Do not use more or less of it and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects while taking too little may not improve your condition.

Procarbazine is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the right time and do not mix them. Ask your health care professional to help you plan a way to take your medicines at the right times.

Procarbazine commonly causes nausea and vomiting. Even if you begin to feel ill, do not stop using this medicine without first checking with your doctor. Ask your health care professional for ways to lessen these effects.

If you vomit shortly after taking a dose of procarbazine, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Matulane

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Check with your doctor or hospital emergency room immediately if severe headache, stiff neck, chest pains, fast heartbeat, or nausea and vomiting occur while you are taking this medicine. These may be symptoms of a serious high blood pressure reaction that should have a doctor's attention.

When taken with certain foods, drinks, or other medicines, procarbazine can cause very dangerous reactions such as sudden high blood pressure. To avoid such reactions, obey the following rules of caution :

• Do not eat foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses, yeast or meat extracts, fava or broad bean pods, smoked or pickled meat, poultry, or fish, fermented sausage (bologna, pepperoni, salami, and summer sausage) or other unfresh meat, or any overripe fruit. If a list of these foods and beverages is not given to you, ask your health care professional to provide one.


• Do not drink alcoholic beverages or alcohol-free or reduced-alcohol beer or wine.


• Do not eat or drink large amounts of caffeine-containing food or beverages, such as chocolate, coffee, tea, or cola.


• Do not take any other medicine unless approved or prescribed by your doctor. This especially includes over-the-counter (OTC) or nonprescription medicine such as that for colds (including nose drops or sprays), cough, asthma, hay fever, appetite control; “keep awake” products; or products that make you sleepy.

After you stop using this medicine you must continue to obey the rules of caution concerning food, drink, and other medication for at least 2 weeks since procarbazine may continue to react with certain foods or other medicines for up to 14 days after you stop taking it.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

While you are being treated with procarbazine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Procarbazine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or should not have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Procarbazine can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.


• Avoid contact sports or other situations where bruising or injury could occur.

For diabetic patients:

• Procarbazine may affect blood sugar levels. While you are using this medicine, be especially careful in testing for sugar in your blood or urine.

If you are going to have surgery (including dental surgery) or emergency treatment tell the medical doctor or dentist in charge that you are using this medicine or have used it within the past 2 weeks.

Your doctor may want you to carry an identification card stating that you are using this medicine.

Matulane Side Effects

Along with their needed effects, medicines like procarbazine can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Rare

• Chest pain (severe)


• enlarged pupils of eyes


• fast or slow heartbeat


• headache (severe)


• increased sensitivity of eyes to light


• increased sweating (possibly with fever or cold, clammy skin)


• stiff or sore neck

Check with your doctor immediately if any of the following side effects occur:

Less common

• Black, tarry stools


• blood in urine or stools


• bloody vomit


• cough or hoarseness


• fever or chills


• lower back or side pain


• painful or difficult urination


• pinpoint red spots on skin


• unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Confusion


• convulsions (seizures)


• cough


• hallucinations (seeing, hearing, or feeling things that are not there)


• missing menstrual periods


• shortness of breath


• thickening of bronchial secretions


• tiredness or weakness (continuing)

Less common

• Diarrhea


• sores in mouth and on lips


• tingling or numbness of fingers or toes


• unsteadiness or awkwardness


• yellow eyes or skin

Rare

• Fainting


• skin rash, hives, or itching


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness


• muscle or joint pain


• muscle twitching


• nausea and vomiting


• nervousness


• nightmares


• trouble in sleeping


• unusual tiredness or weakness

Less common

• Constipation


• darkening of skin


• difficulty in swallowing


• dizziness or lightheadedness when getting up from a lying or sitting position


• dry mouth


• feeling of warmth and redness in face


• headache


• loss of appetite


• mental depression

This medicine may cause a temporary loss of hair in some people. After treatment with procarbazine has ended, normal hair growth should return.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Matulane side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Matulane resources

• Matulane Side Effects (in more detail)
• Matulane Dosage
• Matulane Use in Pregnancy & Breastfeeding
• Drug Images
• Matulane Drug Interactions
• Matulane Support Group
• 0 Reviews for Matulane - Add your own review/rating

• Matulane Prescribing Information (FDA)


• Matulane MedFacts Consumer Leaflet (Wolters Kluwer)


• Matulane Concise Consumer Information (Cerner Multum)


• Matulane Monograph (AHFS DI)


• Procarbazine Professional Patient Advice (Wolters Kluwer)

Compare Matulane with other medications

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azilsartan

ay-zil-SAR-tan me-DOX-oh-mil

Oral route(Tablet)

When pregnancy is detected, discontinue azilsartan medoxomil as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus .

Commonly used brand name(s)

In the U.S.

• Edarbi

Available Dosage Forms:

• Tablet

Pharmacologic Class: Angiotensin II Receptor Antagonist

Uses For azilsartan

Azilsartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Azilsartan is an angiotensin II receptor blocker. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, azilsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

azilsartan is available only with your doctor's prescription.

Before Using azilsartan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For azilsartan, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to azilsartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of azilsartan in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of azilsartan in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking azilsartan, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using azilsartan with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Benazepril


• Enalapril


• Enalaprilat


• Lisinopril


• Moexipril


• Perindopril


• Quinapril


• Ramipril


• Trandolapril

Using azilsartan with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bromfenac


• Celecoxib


• Diclofenac


• Diflunisal


• Etodolac


• Fenoprofen


• Flurbiprofen


• Ibuprofen


• Indomethacin


• Ketoprofen


• Ketorolac


• Magnesium Salicylate


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Nabumetone


• Naproxen


• Nepafenac


• Oxaprozin


• Piroxicam


• Salsalate


• Sulindac


• Tolmetin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of azilsartan. Make sure you tell your doctor if you have any other medical problems, especially:

• Congestive heart failure or


• Kidney problems—Use with caution. May make these conditions worse.

• Electrolyte imbalances (e.g., low levels of salt or sodium in the body) or


• Fluid imbalances (caused by dehydration, vomiting, or diarrhea)—Use with caution. The blood pressure-lowering effects of azilsartan may be increased.

Proper Use of azilsartan

Take azilsartan only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

In addition to taking azilsartan, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that azilsartan will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

azilsartan may be taken with or without food.

azilsartan comes with a patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Dosing

The dose of azilsartan will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of azilsartan. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For high blood pressure:
    
    • Adults—80 milligrams (mg) once a day. Some patients may need 40 mg.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of azilsartan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Protect the medicine from light and moisture. Keep your medicine in the original container until you are ready to use it.

Precautions While Using azilsartan

It is very important that your doctor check your progress at regular visits to make sure azilsartan is working properly. Blood tests may be needed to check for unwanted effects.

Using azilsartan while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using azilsartan, tell your doctor right away.

Dizziness or lightheadedness may occur after the first dose of azilsartan, especially if you have been taking a diuretic (water pill). Make sure you know how you react to azilsartan before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Check with your doctor right away if you become sick while taking azilsartan, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt which may cause low blood pressure.

Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium in the body).

Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

azilsartan Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Blurred vision


• confusion


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• sweating


• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Diarrhea

Rare

• Cough


• dizziness


• lack or loss of strength


• muscle spasm


• nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: azilsartan side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More azilsartan resources

• Azilsartan Side Effects (in more detail)
• Azilsartan Dosage
• Azilsartan Use in Pregnancy & Breastfeeding
• Azilsartan Drug Interactions
• Azilsartan Support Group
• 0 Reviews for Azilsartan - Add your own review/rating

• Azilsartan MedFacts Consumer Leaflet (Wolters Kluwer)


• Edarbi Prescribing Information (FDA)


• Edarbi Consumer Overview

Compare azilsartan with other medications

• High Blood Pressure

Vivotif Berna

Generic Name: typhoid vaccine (live), oral (TYE foid vax EEN)

Brand Names: Vivotif Berna

What is typhoid vaccine?

Typhoid (also called "typhoid fever") is a serious disease caused by Salmonella typhi bacteria. Typhoid can be fatal if left untreated.

Typhoid can cause high fever, muscle aches, severe headache, weakness, confusion or agitation, loss of appetite, stomach pain, diarrhea or constipation, and rose-colored spots on the skin.

Untreated typhoid infection may lead to kidney failure, or intestinal bleeding caused by perforation (forming of a hole), which can be fatal. If the infection spreads to the gallbladder, the infected person may become a chronic carrier of the bacteria that causes typhoid. A carrier may have no symptoms but is capable of spreading the infection to others.

Typhoid is spread through contact with the stool (bowel movements) of a person infected with the bacteria. This usually occurs by eating food or drinking water that has become contaminated with feces from an infected person. Once in the digestive tract, typhoid infection can spread to the blood and other parts of the body.

Typhoid fever is most common in non-industrialized parts of the world, especially Asia, Africa, and Central or South America. People who travel to those regions are at risk of coming into contact with the disease.

The typhoid vaccine is used to help prevent this disease in adults and children who are at least 6 years old. Although not part of a routine immunization schedule in the U.S., typhoid vaccine is recommended for people who travel to areas where the disease is common.

This vaccine works by exposing you to a small amount of the bacteria, which causes your body to develop immunity to the disease.

Typhoid vaccine will not treat an active infection that has already developed in the body, and will not prevent any disease caused by bacteria other than Salmonella typhi.

Like any vaccine, the typhoid vaccine may not provide protection from disease in every person.

What is the most important information I should know about typhoid vaccine?

You should not receive this vaccine if you have ever had an allergic reaction to typhoid vaccine in the past, or if you have fever with any type of infection or illness, or a weak immune system caused by disease or by using certain medicines such as chemotherapy. Typhoid vaccine should not be used in a person who is a typhoid carrier.

Before you receive this vaccine, tell the doctor if you have any illness with vomiting or diarrhea, if you are taking an antibiotic or sulfa drug (Azulfidine, Bactrim, Cotrim, Gantrisin, Septra, SMX-TMP, Sulfazine), or if you plan to start taking an anti-malaria medication within 10 days after receiving typhoid vaccine.

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, the doctor may ask you to wait until you get better before you can receive the vaccine.

The typhoid oral vaccine is given in a series of 4 capsules that are taken 1 per day on alternating days (days 1, 3, 5, and 7). On this alternating-day schedule, you will take 1 capsule every 48 hours for 7 days. You must take each capsule according to the recommended schedule for this vaccine to be effective.

You should complete all doses at least 1 week before your scheduled travel or possible exposure to typhoid.

You must keep typhoid vaccine capsules cold when not in use. Once you receive the capsules from your doctor or pharmacy, take them directly home and place them in the refrigerator. Keep each capsule in the foil blister pack in the refrigerator until you are ready to take it. Do not allow the capsules to freeze.

Like any vaccine, the typhoid vaccine may not provide protection from disease in every person.

In addition to receiving typhoid vaccine, take precautions while traveling such as avoiding raw fruits or vegetables that cannot be peeled, drinks that contain ice, flavored ices that may have been made with contaminated water, unbottled or unboiled water, or any food or beverage purchased from a street vendor.

What should I discuss with my healthcare provider before receiving typhoid vaccine?

Typhoid vaccine should not be used in a person who is a typhoid carrier. You should not receive this vaccine if you have ever had an allergic reaction to typhoid vaccine in the past, or if you have:

• 
  

  fever with any type of infection or illness;

  
  


• 
  

  a weak immune system caused by disease such as HIV/AIDS or cancer; or

  
  


• 
  

  a weak immune system caused by using certain medicines such as chemotherapy.

  
  

You may not be able to receive this vaccine if you have:

• 
  

  stomach flu or any illness with vomiting or diarrhea;

  
  


• 
  

  if you are taking an antibiotic, especially a sulfa drug such as sulfasalazine (Azulfidine, Sulfazine), sulfamethoxazole (Bactrim, Cotrim, Septra, SMX-TMP), or sulfisoxazole (Gantrisin); or

  
  


• 
  

  if you plan to start taking an anti-malaria medication within 10 days after receiving a typhoid oral vaccine.

  
  

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, the doctor may ask you to wait until you get better before you can receive the vaccine.

Vaccines may be harmful to an unborn baby and generally should not be given to a pregnant woman. However, not vaccinating the mother could be more harmful to the baby if the mother becomes infected with a disease that this vaccine could prevent. Your doctor will decide whether you should receive this vaccine, especially if you have a high risk of infection with typhoid. It is not known whether typhoid vaccine passes into breast milk, or if it could harm a nursing baby. Do not receive this vaccine without telling your doctor if you are breast-feeding a baby.

How is typhoid vaccine given?

Typhoid vaccine is recommended for adults and children in the following situations:

• 
  

  people who travel to countries where typhoid fever is common;

  
  


• 
  

  people who will have long-term exposure to food or water that may be contaminated with typhoid;

  
  


• 
  

  people who live with someone who is a typhoid carrier; and

  
  


• 
  

  laboratory workers who may come into contact with Salmonella typhi in a work setting.

  
  

The typhoid oral vaccine is given in a series of 4 capsules that are taken 1 per day on alternating days (days 1, 3, 5, and 7). On this alternating-day schedule, you will take 1 capsule every 48 hours for 7 days. You must take each capsule according to the recommended schedule for this vaccine to be effective.

You should complete all doses at least 1 week before your scheduled travel or possible exposure to typhoid.

You must keep typhoid vaccine capsules cold when not in use. Once you receive the capsules from your doctor or pharmacy, take them directly home and place them in the refrigerator. Keep each capsule in the foil blister pack in the refrigerator until you are ready to take it. Do not allow the capsules to freeze. Take the capsule on an empty stomach, at least 1 hour before a meal.

Swallow the capsule as quickly as possible after placing it in your mouth. Take with a full glass of cold or lukewarm water or other beverage. Do not use warm or hot drinks such as coffee, tea, or warm milk. The liquid you use to help swallow the typhoid vaccine capsule should not be warmer than your body temperature (98.6 degrees F).

Do not crush, chew, or break a typhoid vaccine capsule. Swallow the pill whole. The enteric-coated pill has a special coating to release the vaccine slowly into your body. Breaking the pill could damage this coating.

The complete series of 4 vaccine capsules should provide protection against typhoid for up to 5 years. Another series of 4 capsules is then recommended every 5 years during possible exposure to typhoid. Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the Centers for Disease Control and Prevention (CDC).

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of capsules every 5 years during continued exposure, you may not be fully protected against the disease.

Wash your hands often to help prevent typhoid when you are in an area where contamination is possible.

What happens if I miss a dose?

Contact your doctor if you forget to take a capsule on the scheduled day. You may need to start over to make sure you are fully protected against the disease.

Be sure to receive another series of 4 capsules every 5 years during continued exposure to typhoid.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur when taken as directed.

What should I avoid before or after getting typhoid vaccine?

In addition to receiving typhoid vaccine, take precautions while traveling to further prevent coming into contact with bacteria that cause typhoid fever:

• 
  

  Avoid eating leafy vegetables such as spinach or lettuce, which are harder to wash properly.

  
  


• 
  

  Avoid eating raw fruits or vegetables that cannot be peeled, or that have been peeled by another person.

  
  


• 
  

  Avoid drinks that contain ice, or frozen treats and flavored ices that may have been made with contaminated water.

  
  


• 
  

  Avoid eating foods you have not cooked or prepared yourself. Use clean surfaces and utensils when preparing food.

  
  


• 
  

  Drink only bottled water (carbonated is best) or water that has been boiled for at least 1 minute.

  
  


• 
  

  Avoid any food or beverage purchased from a street vendor.

  
  

Typhoid vaccine side effects

You should not receive a booster dose if you had a life-threatening allergic reaction after taking a typhoid vaccine capsule.

Becoming infected with typhoid is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects include:

• 
  

  low fever;

  
  


• 
  

  headache;

  
  


• 
  

  nausea, vomiting, diarrhea, stomach pain; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect typhoid vaccine?

Before receiving this vaccine, tell the doctor about all other vaccines you have recently received.

You should not take an anti-malaria medication called proguanil (Malarone) for at least 10 days after you have received your last dose of typhoid vaccine. Proguanil may make typhoid vaccine less effective.

There may be other drugs that can affect this vaccine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Vivotif Berna resources

• Vivotif Berna Side Effects (in more detail)
• Vivotif Berna Use in Pregnancy & Breastfeeding
• Vivotif Berna Drug Interactions
• Vivotif Berna Support Group
• 0 Reviews for Vivotif Berna - Add your own review/rating

• typhoid vaccine, live Advanced Consumer (Micromedex) - Includes Dosage Information


• Typhoid Vaccine Monograph (AHFS DI)

Compare Vivotif Berna with other medications

• Typhoid Prophylaxis

Where can I get more information?

• Your doctor or pharmacist may have information about this vaccine written for health professionals that you may read. You may also find additional information from your local health department or the Centers for Disease Control and Prevention.

See also: Vivotif Berna side effects (in more detail)